Natural antioxidant pigment fucoxanthin
Weight management, lowering blood sugar ... This natural antioxidant pigment fucoxanthin extracted from seaweed is not simple at all
As early as 2021, the China Algae Industry Association issued a group standard for "Brown seaweed extract fucoxanthin". Its molecular formula is C42H58O6. The fucoxanthin structure extracted in brown algae is dominated by full anti -type, and its structure is as follows:
Fucoxanthin was first separated by Willstätter and Page from the marine brown seaweed in 1914. Fucoxanthin is actually a kind of carotenoids extracted from dark orange and brown seaweed. When this carotene is observed under a microscope, it is tied with other orange cells as orange. It is natural antioxidant pigment. It accounts for more than 10% of the total amount of carotene can be used in nature. There are many potential influence on human health's physiology, from skin health to metabolic health, which has been confirmed in animal model research. Different keys and unique oxygen -containing groups give the unique structure of fucoxanthin, such as epoxyls, hydroxyls, cymbal groups, and carboxyl groups, which are considered to be partial reasons for giblogenesis to have unique physiological functions. Due to its unique chemical structure and the role of a single compound with multiple target health, it has attracted more and more attention in the scientific community. A large number of scientific evidence supports the potential benefits of promoting human health and disease management.
Fucoxanthin benefits
(1) Antioxidant
Antioxidant activity is one of the important features of carotene. Many biological effects are related to the ability to remove active oxygen, which is one of the reasons for its disease prevention effect. Earlier studies have shown that fucoxanthin is also an effective free radical cleaner. In non -cell experiments in vitro, the fucoxanthin extract extracted in brown algae has antioxidant activity, and its level of removal of DPPH free radicals and the level of iron chewed activity increased, and the restore ability decreases.
In addition, studies have shown that fucoxanthin can effectively inhibit the formation of activated oxygen in the cells, DNA damage, and H2O2 -induced cell apoptosis, which may be related to the increased hydrogenidase. In the study of animal models, after gardenia loblin induced by egg white protein-induced asthma mice, it was found that the formation of ROS intracellular ROS decreased, increased antioxidase activity, alcoholic liver injury mice's total liver antioxidant capacity (T-AOC) , Glutamin Powatase (GSH-PX), superal oxide dismutase (SOD) and peroxidase (CAT) levels increase. Some studies have added fucoxanthin to the sunscreen (0.5% W/V), and it is found that it can significantly suppress the formation of ROS in human skin.
(2) Weight management
Experiment evidence has shown that fucoxanthin has the potential to resist obesity and hyperlipidemia. In a double -blind placebo comparison research carried out by Hitoe et al., To take a capsule containing 1 mg and 3 mg of fucoxanthin for 4 weeks for mild obese men and women. reduce. Interestingly, according to research, fucoxanthin also has a regulatory effect on the intestinal microbial group, which plays a role in controlling weight. In addition, fucoxanthin can also significantly inhibit the growth of Lachnospiraceae and SandyliTricaceae related to obesity/inflammation. At the same time, it promotes lactobacillus/lactococcus, bisidobacterium, and some butyl acid salt. The growth of bacteria is generated to alleviate the intestinal microbial group disorders induced by high -fat diet. Similarly, among the obese mice induced by high-fat diet, replenishment of fucoxanthin can improve obesity, hyperglycemia and hyperlipidemia, and reduce insulin resistance. This may be by adjusting IRS-1 / PI3K / AKT and PPAR standard /Srebp-1/FAS signaling pathway. At the same time, fucoxanthin is improving hyperglycemia, hyperlipidemia and insulin resistance of diabetic mice through IRS-1/Pi3K/AKT and AMPK pathways. Among the fatty liver cells induced by oleic acid, fucoxanthin is significantly inhibited by the SIRT1/AMPK pathway, thereby reducing lipid peroxidation.
(3) Anti -inflammation
The inflammatory response is a self-defense response to various pathogenic stimuli. It is characterized by attracting a large amount of white blood cells (neutral granulocytes, monocular-macrophages, and hypertrophic cells) to inflammation areas. These inflammatory cells are triggered by inflammatory media. Outlets and nitric oxide free radicals can be produced, and it may become a harmful process of self -injury. Anti-inflammatory drugs should be produced by inhibiting inflammatory cytokine such as tumor necrosis factor-α, leukemine -1β, and leukoplastin-6, as well as inflammatory mediators such as induced nitric oxide compound enzymes and cycloidase synthesis Nitrogen oxide and prostaglandin E2 are generated to reduce inflammatory response.
Researchers such as Li and other researchers reported the anti -inflammatory effects of 264.7 macrophages of palm acid activation. The results showed that the inhibitory effects of fucoxanthin in inflammatory leukocyte-6, leukocyte -1β, tumor necrosis factor-α, and NLRP3 inflammatory small body genes weakened, and the expression of AMPK in phosphorylation AMPK was increased. Fucoxanthin has anti -inflammatory effects.
(4) Hypoglycemic action
(4) Studies such as Maeda and Park have shown that fucoxanthin can significantly reduce the aura blood glucose concentration, plasma insulin level, and insulin resistance index of eating obese obese mice. Fucoxanthin may improve the changes in lipid metabolism and insulin resistance caused by high -fat diet. At least part is to reduce the amount of internal fat, high insulin ledmia, liver glucose production, and liver fat production, and changing liver glucose regulatory enzymes.
(5) Others
In addition, fucoxanthin also has the effects of protecting the eyes, liver, bones, and cerebrovascular.
The structure of fucoxanthin has a variety of pharmacological characteristics, including antioxidant and anti -inflammatory activity, and provides synergistic protection for nerves, obesity, liver, diabetes, kidneys, heart, skin, breathing and microbial diseases. The research trend of fucoxanthin has increased sharply. As an emerging market, it is used in pharmaceutical/food supplement products, and the application of the cosmetics industry will be more and more.
Fucoxanthin supplier
Shandong Jiejing Group Corporation was founded in 1968, it is the main drafting unit of Peoples' Republic of China Aquaculture Group Standard "Brown Seaweed Extract Fucoxanthin". And Jiejing is the first manufacturer that can produce high purity fucoxanthin in China. The purity of fucoxanthin is available from 1%, 5%, 10%, 20%, 30%, 50%, 60%, 70%, 80%, 90%, 98%.
